4GKM
Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (AnPRT; trpD)
Summary for 4GKM
| Entry DOI | 10.2210/pdb4gkm/pdb |
| Related | 4GIU |
| Descriptor | Anthranilate phosphoribosyltransferase, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, ... (7 entities in total) |
| Functional Keywords | magnesium binding, phosphoribosylpyrophosphate, prpp, inhibitor complex, bi-anthranilate-like analogue, tb structural genomics consortium, tbsgc, phosphoribosyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 2 |
| Total formula weight | 80194.98 |
| Authors | Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-08-13, release date: 2013-08-14, Last modification date: 2023-09-13) |
| Primary citation | Evans, G.L.,Gamage, S.A.,Bulloch, E.M.,Baker, E.N.,Denny, W.A.,Lott, J.S. Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15:852-864, 2014 Cited by PubMed: 24623674DOI: 10.1002/cbic.201300628 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6683 Å) |
Structure validation
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