Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.5 A)

Summary for 4G7V

Related4G7Y 4G80
Descriptorfragment antibody heavy chain, fragment antibody light chain, Voltage-sensor containing phosphatase, ... (7 entities in total)
Functional Keywordsmembrane protein, alpha helix, fragment antibody, voltage sensing domain, sensing voltage
Biological sourceHomo sapiens
Total number of polymer chains3
Total molecular weight68206.71
Li, Q. (deposition date: 2012-07-20, release date: 2014-02-05, Last modification date: 2017-12-13)
Primary citation
Li, Q.,Wanderling, S.,Paduch, M.,Medovoy, D.,Singharoy, A.,McGreevy, R.,Villalba-Galea, C.A.,Hulse, R.E.,Roux, B.,Schulten, K.,Kossiakoff, A.,Perozo, E.
Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.
Nat. Struct. Mol. Biol., 21:244-252, 2014
PubMed: 24487958 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2768
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2417 0.4% 1.0% 5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25