4G6K

Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its unbound state

Summary for 4G6K

Entry DOI	10.2210/pdb4g6k/pdb
Related	4G5Z 4G6J 4G6M
Descriptor	heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment (3 entities in total)
Functional Keywords	immunoglobulin fold, immune system, cytokine, interleukine-1beta
Biological source	homo Sapiens, Mus musculus (human, mouse) More
Total number of polymer chains	2
Total formula weight	46791.32
Authors	Blech, M.,Hoerer, S. (deposition date: 2012-07-19, release date: 2012-12-19, Last modification date: 2023-09-13)
Primary citation	Blech, M.,Peter, D.,Fischer, P.,Bauer, M.M.,Hafner, M.,Zeeb, M.,Nar, H. One target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425:94-111, 2013 Cited by PubMed: 23041424 DOI: 10.1016/j.jmb.2012.09.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation