4G1N

PKM2 in complex with an activator

Summary for 4G1N

Entry DOI	10.2210/pdb4g1n/pdb
Descriptor	Pyruvate kinase isozymes M1/M2, OXALATE ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	pyruvate kinase, aerobic glycolysis, activator, cancer metabolism, phosphorylation of pyruvate, transferase-activator complex, transferase/activator
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14618
Total number of polymer chains	4
Total formula weight	228027.52
Authors	Kung, C.,Hixon, J.,Dang, L.,DeLaBarre, B.,Qian, K.C. (deposition date: 2012-07-10, release date: 2012-10-10, Last modification date: 2024-02-28)
Primary citation	Kung, C.,Hixon, J.,Choe, S.,Marks, K.,Gross, S.,Murphy, E.,Delabarre, B.,Cianchetta, G.,Sethumadhavan, S.,Wang, X.,Yan, S.,Gao, Y.,Fang, C.,Wei, W.,Jiang, F.,Wang, S.,Qian, K.,Saunders, J.,Driggers, E.,Woo, H.K.,Kunii, K.,Murray, S.,Yang, H.,Yen, K.,Liu, W.,Cantley, L.C.,Vander Heiden, M.G.,Su, S.M.,Jin, S.,Salituro, F.G.,Dang, L. Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy. Chem.Biol., 19:1187-1198, 2012 Cited by PubMed: 22999886 DOI: 10.1016/j.chembiol.2012.07.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation