4G1N
PKM2 in complex with an activator
Summary for 4G1N
Entry DOI | 10.2210/pdb4g1n/pdb |
Descriptor | Pyruvate kinase isozymes M1/M2, OXALATE ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pyruvate kinase, aerobic glycolysis, activator, cancer metabolism, phosphorylation of pyruvate, transferase-activator complex, transferase/activator |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14618 |
Total number of polymer chains | 4 |
Total formula weight | 228027.52 |
Authors | Kung, C.,Hixon, J.,Dang, L.,DeLaBarre, B.,Qian, K.C. (deposition date: 2012-07-10, release date: 2012-10-10, Last modification date: 2024-02-28) |
Primary citation | Kung, C.,Hixon, J.,Choe, S.,Marks, K.,Gross, S.,Murphy, E.,Delabarre, B.,Cianchetta, G.,Sethumadhavan, S.,Wang, X.,Yan, S.,Gao, Y.,Fang, C.,Wei, W.,Jiang, F.,Wang, S.,Qian, K.,Saunders, J.,Driggers, E.,Woo, H.K.,Kunii, K.,Murray, S.,Yang, H.,Yen, K.,Liu, W.,Cantley, L.C.,Vander Heiden, M.G.,Su, S.M.,Jin, S.,Salituro, F.G.,Dang, L. Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy. Chem.Biol., 19:1187-1198, 2012 Cited by PubMed: 22999886DOI: 10.1016/j.chembiol.2012.07.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report