4FIC
Kinase domain of cSrc in complex with a hinge region-binding fragment
Summary for 4FIC
| Entry DOI | 10.2210/pdb4fic/pdb |
| Descriptor | Proto-oncogene tyrosine-protein kinase Src, 6-phenyl[1,2,4]triazolo[1,5-a]pyrazin-2-amine (3 entities in total) |
| Functional Keywords | hinge binding fragment, type i, dfg-in, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Gallus gallus (bantam,chickens) |
| Cellular location | Cell membrane (By similarity): P00523 |
| Total number of polymer chains | 2 |
| Total formula weight | 65875.74 |
| Authors | Richters, A.,Rauh, D. (deposition date: 2012-06-08, release date: 2013-04-10, Last modification date: 2023-09-13) |
| Primary citation | Urich, R.,Wishart, G.,Kiczun, M.,Richters, A.,Tidten-Luksch, N.,Rauh, D.,Sherborne, B.,Wyatt, P.G.,Brenk, R. De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments. Acs Chem.Biol., 8:1044-1052, 2013 Cited by PubMed: 23534475DOI: 10.1021/cb300729y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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