4FHI

Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

Summary for 4FHI

Entry DOI	10.2210/pdb4fhi/pdb
Related	4FHH
Descriptor	Vitamin Nuclear Receptor, SRC-1, N-hydroxy-2-{4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide, ... (4 entities in total)
Functional Keywords	ligand binding domain alpha helical sandwich, alpha helical sandwich, transcription factor, dna coregulators, phosphorylation, nucleus, transcription-protein binding-inhibitor complex, transcription/protein binding/inhibitor
Biological source	Danio Rerio More
Total number of polymer chains	2
Total formula weight	35954.01
Authors	Fischer, J.,Wang, T.T.,Kaldre, D.,Rochel, N.,Moras, D.,White, J.H.,Gleason, J.L. (deposition date: 2012-06-06, release date: 2012-09-19, Last modification date: 2024-02-28)
Primary citation	Fischer, J.,Wang, T.T.,Kaldre, D.,Rochel, N.,Moras, D.,White, J.H.,Gleason, J.L. Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition. Chem.Biol., 19:963-971, 2012 Cited by PubMed: 22921063 DOI: 10.1016/j.chembiol.2012.05.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation