4EPY

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation

Summary for 4EPY

Entry DOI	10.2210/pdb4epy/pdb
Related	4EPR 4EPT 4EPV 4EPW 4EPX
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	small molecule complex crystal structure, kras, p21, gtp-binding protein, oncogenes, binder, hydrolase, inhibitor of sos-mediated activation
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side: P01116
Total number of polymer chains	1
Total formula weight	20181.75
Authors	Sun, Q.,Burke, J.P.,Phan, J.,Burns, M.C.,Olejniczak, E.T.,Waterson, A.G.,Lee, T.,Rossanese, O.W.,Fesik, S.W. (deposition date: 2012-04-17, release date: 2012-05-23, Last modification date: 2023-09-13)
Primary citation	Sun, Q.,Burke, J.P.,Phan, J.,Burns, M.C.,Olejniczak, E.T.,Waterson, A.G.,Lee, T.,Rossanese, O.W.,Fesik, S.W. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew.Chem.Int.Ed.Engl., 51:6140-6143, 2012 Cited by PubMed: 22566140 DOI: 10.1002/anie.201201358 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.801 Å)

Structure validation