4EHQ

Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode

Summary for 4EHQ

Entry DOI	10.2210/pdb4ehq/pdb
Descriptor	Calmodulin, Calcium release-activated calcium channel protein 1, CALCIUM ION, ... (5 entities in total)
Functional Keywords	calmodulin, orai1, calcium dependent inactivation, ef hand, calcium binding, calcium-dependent inactivation, calmodulin binding domain of orai1, none, cytosol, protein binding
Biological source	Rattus norvegicus (brown rat,rat,rats) More
Cellular location	Cytoplasm, cytoskeleton, spindle: P62161 Cell membrane; Multi-pass membrane protein: Q96D31
Total number of polymer chains	2
Total formula weight	19619.91
Authors	Liu, Y.,Zheng, X.,Mueller, G.A.,Sobhany, M.,DeRose, E.F.,Zhang, Y.,London, R.E.,Birnbaumer, L. (deposition date: 2012-04-03, release date: 2012-11-07, Last modification date: 2023-09-13)
Primary citation	Liu, Y.,Zheng, X.,Mueller, G.A.,Sobhany, M.,Derose, E.F.,Zhang, Y.,London, R.E.,Birnbaumer, L. *Crystal structure of calmodulin binding domain of orai1 in complex with ca2+calmodulin displays a unique binding mode.** J.Biol.Chem., 287:43030-43041, 2012 Cited by PubMed: 23109337 DOI: 10.1074/jbc.M112.380964 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9005 Å)

Structure validation