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4EG7

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1331

Summary for 4EG7
Entry DOI10.2210/pdb4eg7/pdb
Related4EG1 4EG3 4EG4 4EG5 4EG6 4EG8 4EGA
DescriptorMethionyl-tRNA synthetase, putative, GLYCEROL, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywordsaminoacyl-trna synthetase, aars, metrs, parasite, ligase, protein-inhibitor complex, rossmann-fold, translation, nucleotide binding, rossmann fold, trna binding atp binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceTrypanosoma brucei brucei
Total number of polymer chains2
Total formula weight125688.37
Authors
Koh, C.Y.,Kim, J.E.,Shibata, S.,Fan, E.,Verlinde, C.L.M.J.,Hol, W.G.J. (deposition date: 2012-03-30, release date: 2012-09-12, Last modification date: 2023-09-13)
Primary citationKoh, C.Y.,Kim, J.E.,Shibata, S.,Ranade, R.M.,Yu, M.,Liu, J.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G.
Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20:1681-1691, 2012
Cited by
PubMed: 22902861
DOI: 10.1016/j.str.2012.07.011
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.747 Å)
Structure validation

217705

數據於2024-03-27公開中

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