4EBQ

Fab structure of anti-Vaccinia virus D8L antigen mouse IgG2a LA5

Summary for 4EBQ

Related4E9O 2I9L
Descriptoranti-Vaccinia D8L antigen monoclonal IgG2a antibody LA5, heavy chain, anti-Vaccinia D8L antigen monoclonal IgG2a antibody LA5, light chain, GLYCEROL, ... (7 entities in total)
Functional Keywordsvariable domain, constant domain, cdr, hypervariable region, neutralizing antibody, vaccinia virus, d8l envelope protein, conformational epitope, discontinuous epitope, d8l antigen binding, neutralizing mab in presence of complement, d8l vaccinia envelope protein, papain treatment, immune system
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total molecular weight47699.57
Authors
Matho, M.H.,Zajonc, D.M. (deposition date: 2012-03-23, release date: 2012-06-06, Last modification date: 2012-07-25)
Primary citation
Matho, M.H.,Maybeno, M.,Benhnia, M.R.,Becker, D.,Meng, X.,Xiang, Y.,Crotty, S.,Peters, B.,Zajonc, D.M.
Structural and Biochemical Characterization of the Vaccinia Virus Envelope Protein D8 and Its Recognition by the Antibody LA5.
J.Virol., 86:8050-8058, 2012
PubMed: 22623786 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.00836-12
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22780.2%0.3%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report