4E45

Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase hFANCM

Summary for 4E45

• Entry DOI: 10.2210/pdb4e45/pdb
• Related: 4E44
• Descriptor: Centromere protein S, Centromere protein X, Fanconi anemia group M protein, ... (6 entities in total)
• Functional Keywords: histone-fold, pentamer, fanconi anemia, helicase, fancm, mhf, dna binding protein-hydrolase complex, dna binding protein/hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q8N2Z9 A8MT69 Q8IYD8
• Total number of polymer chains: 15
• Total formula weight: 182335.39

Authors

Fox III, D.,Zhao, Y.,Yang, W.,Weidong, W. (deposition date: 2012-03-12, release date: 2013-03-20, Last modification date: 2023-09-13)

• Primary citation: Fox III, D.,Yan, Z.,Ling, C.,Zhao, Y.,Lee, D.Y.,Yang, W.,Weidong, W.; Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)