4DWK

Structure of cystein free insulin degrading enzyme with compound bdm41671 ((s)-2-{2-[carboxymethyl-(3-phenyl-propyl)-amino]-acetylamino}-3-(1h-imidazol-4-yl)-propionic acid methyl ester)

Summary for 4DWK

Entry DOI	10.2210/pdb4dwk/pdb
Related	4DTT 4DTV 4DVM 4DVP 4DW9
Descriptor	Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate, ZINC ION, ... (4 entities in total)
Functional Keywords	metalloendopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14735
Total number of polymer chains	2
Total formula weight	230056.86
Authors	Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.J. (deposition date: 2012-02-24, release date: 2013-04-03, Last modification date: 2023-09-13)
Primary citation	Charton, J.,Gauriot, M.,Guo, Q.,Hennuyer, N.,Marechal, X.,Dumont, J.,Hamdane, M.,Pottiez, V.,Landry, V.,Sperandio, O.,Flipo, M.,Buee, L.,Staels, B.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R. Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79:184-193, 2014 Cited by PubMed: 24735644 DOI: 10.1016/j.ejmech.2014.04.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation