4DL5

Human DNA polymerase eta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2).

Summary for 4DL5

• Entry DOI: 10.2210/pdb4dl5/pdb
• Related: 3MR2 3MR3 3MR5 3MR6 3SI8 4DL2 4DL3 4DL4 4DL6 4DL7
• Descriptor: DNA polymerase eta, DNA (5'-D(*TP*AP*CP*GP*GP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(P*TP*AP*GP*TP*GP*TP*GP*AP*C)-3'), ... (6 entities in total)
• Functional Keywords: cisplatin, chemoresistence, translesion synthesis, human dna polymerse eta, kinetics, molecular splint, inhibition, dna distorsion, second tls polymerase, nucleotidyl transfer reaction, pcna, transferase-dna-inhibitor complex, transferase/dna/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9Y253
• Total number of polymer chains: 3
• Total formula weight: 55825.75

Authors

Zhao, Y.,Biertumpfel, C.,Gregory, M.,Hanaoka, F.,Hua, Y.,Yang, W. (deposition date: 2012-02-05, release date: 2012-05-09, Last modification date: 2023-09-13)

• Primary citation: Zhao, Y.,Biertumpfel, C.,Gregory, M.T.,Hua, Y.J.,Hanaoka, F.,Yang, W.; Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta; Proc.Natl.Acad.Sci.USA, 109:7269-7274, 2012; PubMed: 22529383; DOI: 10.1073/pnas.1202681109

Experimental method

X-RAY DIFFRACTION (2.92 Å)