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4DL4

Human DNA polymerase eta inserting dCMPNPP opposite the 3'G of cisplatin crosslinked Gs (Pt-GG1).

Summary for 4DL4
Entry DOI10.2210/pdb4dl4/pdb
Related3MR2 3MR3 3MR5 3MR6 3SI8
DescriptorDNA polymerase eta, DNA (5'-D(P*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... (8 entities in total)
Functional Keywordscisplatin, chemoresistence, translesion synthesis, human dna polymerse eta, kinetics, molecular splint, inhibition, dna distorsion, second tls polymerase, nucleotidyl transfer reaction, pcna, transferase-dna-inhibitor complex, transferase/dna/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: Q9Y253
Total number of polymer chains3
Total formula weight55340.47
Authors
Zhao, Y.,Biertumpfel, C.,Gregory, M.,Hua, Y.-J.,Hanaoka, F.,Yang, W. (deposition date: 2012-02-05, release date: 2012-05-09, Last modification date: 2023-09-13)
Primary citationZhao, Y.,Biertumpfel, C.,Gregory, M.T.,Hua, Y.J.,Hanaoka, F.,Yang, W.
Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109:7269-7274, 2012
Cited by
PubMed: 22529383
DOI: 10.1073/pnas.1202681109
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

数据于2024-03-27公开中

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