4DG1

Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A

4DG1 の概要

• エントリーDOI: 10.2210/pdb4dg1/pdb
• 関連するPDBエントリー: 1DLO 3KLI
• 分子名称: Reverse Transcriptase P66 subunit, Reverse Transcriptase P51 subunit, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: polymorphism 172k, p51/p66, hetero dimer, aids, hiv, resistance mutations, right-hand configuration, rnase h domain, reverse transcriptase, ribonuclease h, rna-directed dna polymerase, dna polymerase, transferase, azt excision, azt unblocking, nevirapine, efavirenz, azt, nucleoside inhibitors, nonnucleoside inhibitors, nrti, nnrti
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114632.33

構造登録者

Tu, X.,Kirby, K.A.,Marchand, B.,Sarafianos, S.G. (登録日: 2012-01-24, 公開日: 2012-06-20, 最終更新日: 2023-09-13)

• 主引用文献: Hachiya, A.,Marchand, B.,Kirby, K.A.,Michailidis, E.,Tu, X.,Palczewski, K.,Ong, Y.T.,Li, Z.,Griffin, D.T.,Schuckmann, M.M.,Tanuma, J.,Oka, S.,Singh, K.,Kodama, E.N.,Sarafianos, S.G.; HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors.; J.Biol.Chem., 287:29988-29999, 2012; PubMed: 22761416; DOI: 10.1074/jbc.M112.351551

実験手法

X-RAY DIFFRACTION (2.15 Å)