4DEG

Crystal structure of c-Met in complex with triazolopyridazine inhibitor 2

Summary for 4DEG

• Entry DOI: 10.2210/pdb4deg/pdb
• Related: 4DEH 4DEI
• Descriptor: Hepatocyte growth factor receptor, 7-methoxy-N-{[6-(3-methyl-1,2-thiazol-5-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}-1,5-naphthyridin-4-amine (3 entities in total)
• Functional Keywords: proto-oncogene, receptor tyrosine kinase, rtk, atp-binding, hepatocyte growth factor/scatter factor, hgf/sf, phosphoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• Total number of polymer chains: 1
• Total formula weight: 35620.16

Authors

Whittington, D.A.,Bellon, S.F.,Long, A.M. (deposition date: 2012-01-20, release date: 2012-05-30, Last modification date: 2024-02-28)

• Primary citation: Bode, C.M.,Boezio, A.A.,Albrecht, B.K.,Bellon, S.F.,Berry, L.,Broome, M.A.,Choquette, D.,Dussault, I.,Lewis, R.T.,Lin, M.H.,Rex, K.,Whittington, D.A.,Yang, Y.,Harmange, J.C.; Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.; Bioorg.Med.Chem.Lett., 22:4089-4093, 2012; PubMed: 22595176; DOI: 10.1016/j.bmcl.2012.04.072

Experimental method

X-RAY DIFFRACTION (2 Å)