4CXN

Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form I

Summary for 4CXN

• Entry DOI: 10.2210/pdb4cxn/pdb
• Related: 4CXL
• Descriptor: INSULIN A CHAIN, INSULIN B CHAIN (3 entities in total)
• Functional Keywords: hormone, diabetes
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 2
• Total formula weight: 5845.70

Authors

Kosinova, L.,Veverka, V.,Novotna, P.,Collinsova, M.,Urbanova, M.,Jiracek, J.,Moody, N.R.,Turkenburg, J.P.,Brzozowski, A.M.,Zakova, L. (deposition date: 2014-04-07, release date: 2014-05-28, Last modification date: 2023-12-20)

• Primary citation: Kosinova, L.,Veverka, V.,Novotna, P.,Collinsova, M.,Urbanova, M.,Moody, N.R.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.,Zakova, L.; An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.; Biochemistry, 53:3392-, 2014; PubMed: 24819248; DOI: 10.1021/BI500073Z

Experimental method

X-RAY DIFFRACTION (1.7 Å)