4CU1

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-[(2S)-3-amino-2-{5-[2-(6-amino-4-methylpyridin-2-yl)ethyl]pyridin-3-yl}propyl]-4-methylpyridin-2-amine

Summary for 4CU1

• Entry DOI: 10.2210/pdb4cu1/pdb
• Related: 4CTP 4CTQ 4CTR 4CTT 4CTU 4CTV 4CTW 4CTX 4CTY 4CTZ 4CU0
• Descriptor: NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total)
• Functional Keywords: oxidoreductase, inhibitor complex
• Biological source: BOS TAURUS (CATTLE); More
• Cellular location: Cell membrane: P29473 P29473
• Total number of polymer chains: 2
• Total formula weight: 102186.19

Authors

Li, H.,Poulos, T.L. (deposition date: 2014-03-15, release date: 2014-05-07, Last modification date: 2014-06-04)

• Primary citation: Kang, S.,Tang, W.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity.; J.Med.Chem., 57:4382-, 2014; PubMed: 24758147; DOI: 10.1021/JM5004182

Experimental method

X-RAY DIFFRACTION (1.89 Å)