4CIB
crystal structure of cathepsin a, complexed with compound 2
Summary for 4CIB
Entry DOI | 10.2210/pdb4cib/pdb |
Related | 4CI9 4CIA |
Descriptor | LYSOSOMAL PROTECTIVE PROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-(cyclohexylmethyl)propanedioic acid, ... (5 entities in total) |
Functional Keywords | hydrolase, drug discovery, serine carboxypeptidase, cardiovascular drug, heart failure, endothelin, tetrahedral intermediate, covalent inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 53440.45 |
Authors | Schreuder, H.A.,Liesum, A.,Kroll, K.,Boehnisch, B.,Buning, C.,Ruf, S.,Buning, C.,Sadowski, T. (deposition date: 2013-12-06, release date: 2014-02-26, Last modification date: 2023-12-20) |
Primary citation | Schreuder, H.A.,Liesum, A.,Kroll, K.,Bohnisch, B.,Buning, C.,Ruf, S.,Sadowski, T. Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases. Biochem. Biophys. Res. Commun., 445:451-456, 2014 Cited by PubMed: 24530914DOI: 10.1016/j.bbrc.2014.02.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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