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4C6E

Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 5.5

Summary for 4C6E
Entry DOI10.2210/pdb4c6e/pdb
Related4C6B 4C6C 4C6D 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P 4C6Q
DescriptorDIHYDROOROTASE, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, N-CARBAMOYL-L-ASPARTATE, ... (6 entities in total)
Functional Keywordshydrolase, de novo pyrimidine biosynthesis, amidohydrolase superfamily, metalloenzyme, zinc binding, histidinate anion
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P27708
Total number of polymer chains1
Total formula weight43565.18
Authors
Ramon-Maiques, S.,Lallous, N.,Grande-Garcia, A. (deposition date: 2013-09-18, release date: 2014-02-05, Last modification date: 2023-12-20)
Primary citationGrande-Garcia, A.,Lallous, N.,Diaz-Tejada, C.,Ramon-Maiques, S.
Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22:185-, 2014
Cited by
PubMed: 24332717
DOI: 10.1016/J.STR.2013.10.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.263 Å)
Structure validation

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