4BW5

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)

4BW5 の概要

• エントリーDOI: 10.2210/pdb4bw5/pdb
• 分子名称: POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, CADMIUM ION, ... (4 entities in total)
• 機能のキーワード: transport protein, outward rectification, membrane protein, k2p
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126358.34

構造登録者

Pike, A.C.W.,Dong, Y.Y.,Dong, L.,Quigley, A.,Shrestha, L.,Mukhopadhyay, S.,Strain-Damerell, C.,Goubin, S.,Grieben, M.,Shintre, C.A.,Mackenzie, A.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Burgess-Brown, N.,Carpenter, E.P. (登録日: 2013-06-30, 公開日: 2013-07-31, 最終更新日: 2023-12-20)

• 主引用文献: Pike, A.C.W.,Mackenzie, A.,Mcclenaghan, C.,Aryal, P.,Dong, L.,Quigley, A.,Grieben, M.,Goubin, S.,Mukhopadhyay, S.,Ruda, G.F.,Clausen, M.V.,Cao, L.,Brennan, P.E.,Burgess-Brown, N.A.,Sansom, M.S.P.,Tucker, S.J.,Carpenter, E.P.; K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac; Science, 347:1256-, 2015; PubMed: 25766236; DOI: 10.1126/SCIENCE.1261512

実験手法

X-RAY DIFFRACTION (3.2 Å)