4BQG

structure of HSP90 with an inhibitor bound

Summary for 4BQG

Entry DOI	10.2210/pdb4bqg/pdb
Related	4BQJ
Descriptor	HSP90AA1 PROTEIN, 5-(3,4-dichloro-phenoxy)-benzene-1,3-diol (3 entities in total)
Functional Keywords	chaperone
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	26082.03
Authors	Casale, E.,Brasca, M.G.,Mantegani, S.,Amboldi, N.,Bindi, S.,Caronni, D.,Ceccarelli, W.,Colombo, N.,DePonti, A.,Donati, D.,Ermoli, A.,Fachin, G.,Felder, E.R.,Ferguson, R.D.,Fiorelli, C.,Guanci, M.,Isacchi, A.,Pesenti, E.,Polucci, P.,Riceputi, L.,Sola, F.,Visco, C.,Zuccotto, F.,Fogliatto, G. (deposition date: 2013-05-30, release date: 2013-10-23, Last modification date: 2017-06-28)
Primary citation	Brasca, M.G.,Mantegani, S.,Amboldi, N.,Bindi, S.,Caronni, D.,Casale, E.,Ceccarelli, W.,Colombo, N.,De Ponti, A.,Donati, D.,Ermoli, A.,Fachin, G.,Felder, E.R.,Ferguson, R.D.,Fiorelli, C.,Guanci, M.,Isacchi, A.,Pesenti, E.,Polucci, P.,Riceputi, L.,Sola, F.,Visco, C.,Zuccotto, F.,Fogliatto, G. Discovery of Nms-E973 as Novel, Selective and Potent Inhibitor of Heat Shock Protein 90 (Hsp90). Bioorg.Med.Chem., 21:7047-, 2013 Cited by PubMed: 24100158 DOI: 10.1016/J.BMC.2013.09.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation