4BGQ

Crystal structure of the human CDKL5 kinase domain

Summary for 4BGQ

• Entry DOI: 10.2210/pdb4bgq/pdb
• Descriptor: CYCLIN-DEPENDENT KINASE-LIKE 5, SODIUM ION, [4-({4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, ... (6 entities in total)
• Functional Keywords: transferase, phospho-mimetic, kinase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : O76039
• Total number of polymer chains: 1
• Total formula weight: 35856.35

Authors

Canning, P.,Krojer, T.,Goubin, S.,Mahajan, P.,Vollmar, M.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2013-03-28, release date: 2013-05-08, Last modification date: 2023-12-20)

• Primary citation: Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R.; CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.; Cell Rep, 22:885-894, 2018; PubMed: 29420175; DOI: 10.1016/j.celrep.2017.12.083

Experimental method

X-RAY DIFFRACTION (2 Å)