4BCP

Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Summary for 4BCP

• Entry DOI: 10.2210/pdb4bcp/pdb
• Related: 4BCF 4BCG 4BCH 4BCI 4BCJ 4BCK 4BCM 4BCN 4BCO 4BCQ
• Descriptor: CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ... (6 entities in total)
• Functional Keywords: transferase-cell cycle complex, cdk-cyclin complex, cyclin-inhibitor, structure-based drug design, transferase/cell cycle
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941; Nucleus: P20248
• Total number of polymer chains: 4
• Total formula weight: 129866.31

Authors

Hole, A.J.,Baumli, S.,Wang, S.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2012-10-02, release date: 2013-04-17, Last modification date: 2013-08-07)

• Primary citation: Shao, H.,Shi, S.,Huang, S.,Hole, A.,Abbas, A.Y.,Baumli, S.,Liu, X.,Lam, F.,Foley, D.W.,Fischer, P.M.,Noble, M.,Endicott, J.A.,Pepper, C.,Wang, S.; Substituted 4-(Thiazol-5-Yl)-2-(Phenylamino)Pyrimidines are Highly Active Cdk9 Inhibitors: Synthesis, X-Ray Crystal Structure, Sar and Anti-Cancer Activities.; J.Med.Chem., 56:640-, 2013; PubMed: 23301767; DOI: 10.1021/JM301475F

Experimental method

X-RAY DIFFRACTION (2.26 Å)