4B2X

Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor

Summary for 4B2X

• Entry DOI: 10.2210/pdb4b2x/pdb
• Related: 1FXO 1FZW 1G0R 1G1L 1G23 1G2V 1G3L
• Descriptor: GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: transferase
• Biological source: PSEUDOMONAS AERUGINOSA
• Total number of polymer chains: 4
• Total formula weight: 136058.89

Authors

Alphey, M.S.,Pirrie, L.,Torrie, L.S.,Gardiner, M.,Sarkar, A.,Brenk, R.,Westwood, N.J.,Gray, D.,Naismith, J.H. (deposition date: 2012-07-18, release date: 2012-10-31, Last modification date: 2023-12-20)

• Primary citation: Alphey, M.S.,Pirrie, L.,Torrie, L.S.,Boulkeroua, W.A.,Gardiner, M.,Sarkar, A.,Maringer, M.,Oehlmann, W.,Brenk, R.,Scherman, M.S.,McNeil, M.,Rejzek, M.,Field, R.A.,Singh, M.,Gray, D.,Westwood, N.J.,Naismith, J.H.; Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.; ACS Chem. Biol., 8:387-396, 2013; PubMed: 23138692; DOI: 10.1021/cb300426u

Experimental method

X-RAY DIFFRACTION (1.7 Å)