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4B0B

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with 3-(pyridin-2-yloxy)aniline

Summary for 4B0B
Entry DOI10.2210/pdb4b0b/pdb
Related4B0C 4B0I 4B8U 4FQ9
Descriptor3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, 3-(pyridin-2-yloxy)aniline (3 entities in total)
Functional Keywordslyase, fatty acid biosynthesis, bacterial virulence, drug discovery
Biological sourcePSEUDOMONAS AERUGINOSA
Cellular locationCytoplasm (By similarity): O33877
Total number of polymer chains2
Total formula weight37909.49
Authors
Moynie, L.,McMahon, S.A.,Duthie, F.G.,Taylor, J.W.,Naismith, J.H. (deposition date: 2012-07-01, release date: 2012-11-28, Last modification date: 2023-12-20)
Primary citationMoynie, L.,Leckie, S.M.,McMahon, S.A.,Duthie, F.G.,Koehnke, A.,Taylor, J.W.,Alphey, M.S.,Brenk, R.,Smith, A.D.,Naismith, J.H.
Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonasaeruginosa.
J.Mol.Biol., 425:365-, 2013
Cited by
PubMed: 23174186
DOI: 10.1016/J.JMB.2012.11.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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