4AQH

Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976

Summary for 4AQH

Entry DOI	10.2210/pdb4aqh/pdb
Related	1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 9PAI
Descriptor	PLASMINOGEN ACTIVATOR INHIBITOR 1, TERT-BUTYL 3-[(4-OXO-3H-PYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]AZETIDINE-1-CARBOXYLATE (3 entities in total)
Functional Keywords	hydolase inhibitor, latent form
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	3
Total formula weight	130649.66
Authors	Fjellstrom, O.,Deinum, J.,Sjogren, T.,Johansson, C.,Geschwindner, S.,Nerme, V.,Legnehed, A.,McPheat, J.,Olsson, K.,Bodin, C.,Gustafsson, D. (deposition date: 2012-04-17, release date: 2012-11-28, Last modification date: 2023-12-20)
Primary citation	Fjellstrom, O.,Deinum, J.,Sjogren, T.,Johansson, C.,Geschwindner, S.,Nerme, V.,Legnehed, A.,Mcpheat, J.,Olsson, K.,Bodin, C.,Panuovic, A.,Gustafsson, D. Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 that Accelerates the Transition Into the Latent Conformation J.Biol.Chem., 288:873-, 2013 Cited by PubMed: 23155046 DOI: 10.1074/JBC.M112.371732 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation