4AKJ

Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin

Summary for 4AKJ

Entry DOI	10.2210/pdb4akj/pdb
Related	1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2H67 2HH4 2HHO 2HIU 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 5AIY
Descriptor	INSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ... (7 entities in total)
Functional Keywords	hormone
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted: P01308 P01308
Total number of polymer chains	4
Total formula weight	12238.56
Authors	Steensgaard, D.B.,Schluckebier, G.,Strauss, H.M.,Norrman, M.,Thomsen, J.K.,Friderichsen, A.V.,Havelund, S.,Jonassen, I. (deposition date: 2012-02-23, release date: 2013-01-09, Last modification date: 2023-12-20)
Primary citation	Steensgaard, D.B.,Schluckebier, G.,Strauss, H.M.,Norrman, M.,Thomsen, J.K.,Friderichsen, A.V.,Havelund, S.,Jonassen, I. Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52:295-, 2013 Cited by PubMed: 23256685 DOI: 10.1021/BI3008609 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation