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4ZNH

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with a 2-Fluoro-substituted OBHS derivative

Summary for 4ZNH
Entry DOI10.2210/pdb4znh/pdb
Related4PP6 4ZN7 4ZN9 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW
DescriptorEstrogen receptor, Nuclear receptor-interacting peptide, 2-fluorophenyl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
Biological sourceHomo sapiens (Human)
More
Cellular locationIsoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Nucleus: Q15596
Total number of polymer chains4
Total formula weight63182.05
Authors
Primary citationNwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Nowak, J.,Wright, N.J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W.
Predictive features of ligand-specific signaling through the estrogen receptor.
Mol.Syst.Biol., 12:864-864, 2016
Cited by
PubMed: 27107013
DOI: 10.15252/msb.20156701
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.933 Å)
Structure validation

217705

건을2024-03-27부터공개중

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