4XOG
CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH Optactin and DANA
Summary for 4XOG
Entry DOI | 10.2210/pdb4xog/pdb |
Descriptor | Sialidase B, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, ... (5 entities in total) |
Functional Keywords | hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts |
Biological source | Streptococcus pneumoniae TIGR4 |
Total number of polymer chains | 1 |
Total formula weight | 74539.12 |
Authors | Brear, P. (deposition date: 2015-01-16, release date: 2016-02-03, Last modification date: 2024-01-10) |
Primary citation | Rogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J. The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published, |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
Download full validation report