4XLD
Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction
Summary for 4XLD
Entry DOI | 10.2210/pdb4xld/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, FORMIC ACID, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... (4 entities in total) |
Functional Keywords | nuclear receptor ligand screening, gene regulation |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 1 |
Total formula weight | 34155.52 |
Authors | Delfosse, V.,Guichou, J.-F. (deposition date: 2015-01-13, release date: 2015-08-12, Last modification date: 2024-01-10) |
Primary citation | Gelin, M.,Delfosse, V.,Allemand, F.,Hoh, F.,Sallaz-Damaz, Y.,Pirocchi, M.,Bourguet, W.,Ferrer, J.L.,Labesse, G.,Guichou, J.F. Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71:1777-1787, 2015 Cited by PubMed: 26249358DOI: 10.1107/S1399004715010342 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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