4UIS

The cryoEM structure of human gamma-Secretase complex

Summary for 4UIS

• Entry DOI: 10.2210/pdb4uis/pdb
• EMDB information: 2974
• Descriptor: GAMMA-SECRETASE, LYSOZYME, ... (5 entities in total)
• Functional Keywords: hydrolase, gamma-secretase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Host cytoplasm : A0A097J809
• Total number of polymer chains: 5
• Total formula weight: 127307.88

Authors

Sun, L.,Zhao, L.,Yang, G.,Yan, C.,Zhou, R.,Zhou, X.,Xie, T.,Zhao, Y.,Wu, S.,Li, X.,Shi, Y. (deposition date: 2015-04-03, release date: 2015-06-10, Last modification date: 2017-08-02)

• Primary citation: Sun, L.,Zhao, L.,Yang, G.,Yan, C.,Zhou, R.,Zhou, X.,Xie, T.,Zhao, Y.,Wu, S.,Li, X.,Shi, Y.; Structural Basis of Human Gamma-Secretase Assembly.; Proc.Natl.Acad.Sci.USA, 112:6003-, 2015; PubMed: 25918421; DOI: 10.1073/PNAS.1506242112

Experimental method

ELECTRON MICROSCOPY (4.4 Å)