4RN6

Structure of prethrombin-2 mutant s195a bound to the active site inhibitor argatroban

Replaces:  4HFY

Summary for 4RN6

• Entry DOI: 10.2210/pdb4rn6/pdb
• Related: 3SQH
• Related PRD ID: PRD_000889
• Descriptor: Thrombin heavy chain, (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid (2 entities in total)
• Functional Keywords: serine protease, prethrombin-2, autoactivation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space: P00734
• Total number of polymer chains: 2
• Total formula weight: 67803.81

Authors

Pozzi, N.,Chen, Z.,Zapata, F.,Niu, W.,Barranco-Medina, S.,Pelc, L.A.,Di Cera, E. (deposition date: 2014-10-23, release date: 2014-11-05, Last modification date: 2023-09-20)

• Primary citation: Pozzi, N.,Chen, Z.,Zapata, F.,Niu, W.,Barranco-Medina, S.,Pelc, L.A.,Di Cera, E.; Autoactivation of thrombin precursors.; J.Biol.Chem., 288:11601-11610, 2013; PubMed: 23467412; DOI: 10.1074/jbc.M113.451542

Experimental method

X-RAY DIFFRACTION (3 Å)