4R8H

The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein

Summary for 4R8H

Entry DOI	10.2210/pdb4r8h/pdb
Descriptor	cAMP-activated global transcriptional regulator CRP, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, GLYCEROL, ... (4 entities in total)
Functional Keywords	transcription factor, transcription
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	52181.70
Authors	Townsend, P.D.,Pohl, E.,McLeish, T.C.B.,Rodgers, T.L.,Glover, L.C.,Korhonen, H.J.,Wilson, M.R.,Hodgson, D.R.W.,Cann, M.J. (deposition date: 2014-09-02, release date: 2015-07-22, Last modification date: 2024-02-28)
Primary citation	Townsend, P.D.,Rodgers, T.L.,Glover, L.C.,Korhonen, H.J.,Richards, S.A.,Colwell, L.J.,Pohl, E.,Wilson, M.R.,Hodgson, D.R.,McLeish, T.C.,Cann, M.J. The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein. J.Biol.Chem., 290:22225-22235, 2015 Cited by PubMed: 26187469 DOI: 10.1074/jbc.M115.669267 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation