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4RAL

Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta

Replaces:  4QLD
Summary for 4RAL
Entry DOI10.2210/pdb4ral/pdb
DescriptorInsulin-degrading enzyme, C-C motif chemokine 4, ZINC ION, ... (4 entities in total)
Functional Keywordside, mip1alpha, metal-binding, metalloprotease, chemotaxis, inflammatory response, hydrolase-cytokine complex, hydrolase/cytokine
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P14735
Secreted: P13236
Total number of polymer chains4
Total formula weight244901.46
Authors
Liang, W.G.,Ren, M.,Guo, Q.,Tang, W.J. (deposition date: 2014-09-10, release date: 2015-05-13, Last modification date: 2023-09-20)
Primary citationLiang, W.G.,Ren, M.,Zhao, F.,Tang, W.J.
Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427:1345-1358, 2015
Cited by
PubMed: 25636406
DOI: 10.1016/j.jmb.2015.01.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.148 Å)
Structure validation

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