4QGW
Crystal sturcture of the R132K:R111L:L121D mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.77 angstrom resolution
Summary for 4QGW
| Entry DOI | 10.2210/pdb4qgw/pdb |
| Related | 2G7B 3F8A 3FEP 4EEJ 4EXZ 4I9R 4QGV 4QGX |
| Descriptor | Cellular retinoic acid-binding protein 2, (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
| Functional Keywords | protein engineering, protein fluorescence, merocyanine dyes for fluorescent protein labeling, fluorescent protein tag, merocyanine protonated schiff base iminium, protein binding |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P29373 |
| Total number of polymer chains | 2 |
| Total formula weight | 31573.07 |
| Authors | Nosrati, M.,Yapici, I.,Geiger, J.H. (deposition date: 2014-05-26, release date: 2015-01-28, Last modification date: 2015-02-11) |
| Primary citation | Yapici, I.,Lee, K.S.,Berbasova, T.,Nosrati, M.,Jia, X.,Vasileiou, C.,Wang, W.,Santos, E.M.,Geiger, J.H.,Borhan, B. "Turn-on" protein fluorescence: in situ formation of cyanine dyes. J.Am.Chem.Soc., 137:1073-1080, 2015 Cited by PubMed: 25534273DOI: 10.1021/ja506376j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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