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4QFR

Structure of AMPK in complex with Cl-A769662 activator and STAUROSPORINE inhibitor

Summary for 4QFR
Entry DOI10.2210/pdb4qfr/pdb
Related4QFG 4QFS
Descriptor5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total)
Functional Keywordscbm, ampk, kinase, signaling protein-inhibitor-activator complex, signaling protein/inhibitor/activator
Biological sourceRattus norvegicus (brown rat,rat,rats)
More
Cellular locationCytoplasm : P54645
Total number of polymer chains3
Total formula weight120514.84
Authors
Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2014-05-21, release date: 2014-08-06, Last modification date: 2017-11-22)
Primary citationCalabrese, M.F.,Rajamohan, F.,Harris, M.S.,Caspers, N.L.,Magyar, R.,Withka, J.M.,Wang, H.,Borzilleri, K.A.,Sahasrabudhe, P.V.,Hoth, L.R.,Geoghegan, K.F.,Han, S.,Brown, J.,Subashi, T.A.,Reyes, A.R.,Frisbie, R.K.,Ward, J.,Miller, R.A.,Landro, J.A.,Londregan, A.T.,Carpino, P.A.,Cabral, S.,Smith, A.C.,Conn, E.L.,Cameron, K.O.,Qiu, X.,Kurumbail, R.G.
Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms.
Structure, 22:1161-1172, 2014
Cited by
PubMed: 25066137
DOI: 10.1016/j.str.2014.06.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.34 Å)
Structure validation

217705

數據於2024-03-27公開中

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