4PP6

Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Resveratrol

Summary for 4PP6

• Entry DOI: 10.2210/pdb4pp6/pdb
• Related: 4PPP 4PPS
• Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, RESVERATROL, ... (4 entities in total)
• Functional Keywords: nuclear hormone receptor, transcription factor, ligand binding, nucleus, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Nucleus. Isoform 3: Nucleus. Nucleus: P03372; Nucleus: Q15596
• Total number of polymer chains: 4
• Total formula weight: 58398.82

Authors

Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Parent, A.A.,Hughes, T.S.,Pollock, J.A.,Gjyshi, O.,Cavett, V.,Nowak, J.,Garcia-Ordonez, R.D.,Houtman, R.,Griffin, P.R.,Kojetin, D.J.,Katzenellenbogen, J.A.,Conkright, M.D.,Nettles, K.W. (deposition date: 2014-02-26, release date: 2014-05-07, Last modification date: 2023-09-20)

• Primary citation: Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Parent, A.A.,Hughes, T.S.,Pollock, J.A.,Gjyshi, O.,Cavett, V.,Nowak, J.,Garcia-Ordonez, R.D.,Houtman, R.,Griffin, P.R.,Kojetin, D.J.,Katzenellenbogen, J.A.,Conkright, M.D.,Nettles, K.W.; Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network.; Elife, 3:e02057-e02057, 2014; PubMed: 24771768; DOI: 10.7554/eLife.02057

Experimental method

X-RAY DIFFRACTION (2.201 Å)