4P2H

Structure of human DNA polymerase complexed with N7MG in the template opposite to incoming non-hydrolyzable TTP with manganese in the active site

Summary for 4P2H

• Entry DOI: 10.2210/pdb4p2h/pdb
• Related: 1bpx
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... (8 entities in total)
• Functional Keywords: nucleotidyl transfer, dna binding, dna polymerase fold, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 47317.68

Authors

Lee, S.,Koag, M.C. (deposition date: 2014-03-04, release date: 2014-06-25, Last modification date: 2023-09-27)

• Primary citation: Koag, M.C.,Kou, Y.,Ouzon-Shubeita, H.,Lee, S.; Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.; Nucleic Acids Res., 42:8755-8766, 2014; PubMed: 24966350; DOI: 10.1093/nar/gku554

Experimental method

X-RAY DIFFRACTION (1.987 Å)