4ONT
Ternary host recognition complex of complement factor H, C3d, and sialic acid
Summary for 4ONT
Entry DOI | 10.2210/pdb4ont/pdb |
Descriptor | Complement factor H, Complement C3d fragment, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | complement control protein, ccp, short consensus repeat, scr, sushi domain, complement regulation, sialic acid, host glycan, host cell surface, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08603 P01024 |
Total number of polymer chains | 6 |
Total formula weight | 153200.01 |
Authors | Blaum, B.S.,Stehle, T.S. (deposition date: 2014-01-29, release date: 2014-11-26, Last modification date: 2023-09-20) |
Primary citation | Blaum, B.S.,Hannan, J.P.,Herbert, A.P.,Kavanagh, D.,Uhrin, D.,Stehle, T. Structural basis for sialic acid-mediated self-recognition by complement factor H. Nat.Chem.Biol., 11:77-82, 2015 Cited by PubMed: 25402769DOI: 10.1038/nchembio.1696 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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