4V9R

Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome

This is a non-PDB format compatible entry.

Summary for 4V9R

• Entry DOI: 10.2210/pdb4v9r/pdb
• Related PRD ID: PRD_001218
• Descriptor: 16S Ribosomal RNA, 30S Ribosomal Protein S10, 30S Ribosomal Protein S11, ... (61 entities in total)
• Functional Keywords: 70s, ribosome, dityromycin, ge82832, ribosomal protein s12, ef-g, translocation, dityromycin and ge82832 bind protein s12 and block ef-g catalyzed translocation, 30s subunit with bound mrna, p-site trna, ribosome-antibiotic complex, ribosome/antibiotic
• Biological source: Thermus thermophilus; More
• Total number of polymer chains: 110
• Total formula weight: 4455124.47

Authors

Bulkley, D.P.,Brandi, L.,Polikanov, Y.S.,Fabbretti, A.,O'Connor, M.,Gualerzi, C.O.,Steitz, T.A. (deposition date: 2013-12-05, release date: 2014-07-09, Last modification date: 2014-12-10)

• Primary citation: Bulkley, D.,Brandi, L.,Polikanov, Y.S.,Fabbretti, A.,O'Connor, M.,Gualerzi, C.O.,Steitz, T.A.; The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.; Cell Rep, 6:357-365, 2014; PubMed: 24412368; DOI: 10.1016/j.celrep.2013.12.024

Experimental method

X-RAY DIFFRACTION (3 Å)