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4LW1

Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions

Summary for 4LW1
Entry DOI10.2210/pdb4lw1/pdb
Related4LUO 4LUV 4LUZ 4LWC
DescriptorReplication protein A 70 kDa DNA-binding subunit, 5-(3-chloro-4-fluorophenyl)furan-2-carboxylic acid (3 entities in total)
Functional Keywordsob-fold, protein-protein interaction, dna binding protein-inhibitor complex, dna binding protein/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P27694
Total number of polymer chains1
Total formula weight13978.96
Authors
Feldkamp, M.D.,Frank, A.O.,Kennedy, J.P.,Waterson, A.G.,Olejnczak, E.O.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2013-07-26, release date: 2013-12-11, Last modification date: 2023-09-20)
Primary citationFrank, A.O.,Feldkamp, M.D.,Kennedy, J.P.,Waterson, A.G.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W.
Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.
J.Med.Chem., 56:9242-9250, 2013
Cited by
PubMed: 24147804
DOI: 10.1021/jm401333u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.631 Å)
Structure validation

217705

數據於2024-03-27公開中

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