4LEO
Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3)
Summary for 4LEO
Entry DOI | 10.2210/pdb4leo/pdb |
Descriptor | RG7116 Fab heavy chain, RG7116 Fab light chain, Receptor tyrosine-protein kinase erbB-3, ... (6 entities in total) |
Functional Keywords | fab fragment, therapeutic antibody, her3 receptor, transferase-immune system complex, transferase/immune system |
Biological source | Mus musculus (mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 118509.99 |
Authors | Schiller, C.B.,Hopfner, K.P. (deposition date: 2013-06-26, release date: 2013-07-10, Last modification date: 2020-07-29) |
Primary citation | Mirschberger, C.,Schiller, C.B.,Schraml, M.,Dimoudis, N.,Friess, T.,Gerdes, C.A.,Reiff, U.,Lifke, V.,Hoelzlwimmer, G.,Kolm, I.,Hopfner, K.P.,Niederfellner, G.,Bossenmaier, B. RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation. Cancer Res., 73:5183-5194, 2013 Cited by PubMed: 23780344DOI: 10.1158/0008-5472.CAN-13-0099 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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