4KGQ

Crystal structure of a human light loop mutant in complex with dcr3

4KGQ の概要

• エントリーDOI: 10.2210/pdb4kgq/pdb
• 関連するPDBエントリー: 3K51 3MHD 3MI8 4EN0 4J6G
• 分子名称: Tumor necrosis factor receptor superfamily member 6B, Tumor necrosis factor ligand superfamily member 14, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: light, dcr3, tnf, tnfr, tnf14, structural genomics, psi-biology, new hvem, n-glycosylation, membrane, secreted protein, cytokine, ifn, jelly-roll fold, bind tnf receptor hvem and ltbr, ltbr, protein structure initiative, atoms-to-animals: the immune function network, new york structural genomics research consortium, nysgrc, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 74019.27

構造登録者

Liu, W.,Zhan, C.,Bonanno, J.B.,Sampathkumar, P.,Toro, R.,Nathenson, S.G.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC),Atoms-to-Animals: The Immune Function Network (IFN) (登録日: 2013-04-29, 公開日: 2013-07-10, 最終更新日: 2023-09-20)

• 主引用文献: Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C.; Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.; Structure, 22:1252-1262, 2014; PubMed: 25087510; DOI: 10.1016/j.str.2014.06.013

実験手法

X-RAY DIFFRACTION (2.27 Å)