4KAI

HCV NS5B GT1B N316 with GSK5852A

4KAI の概要

• エントリーDOI: 10.2210/pdb4kai/pdb
• 関連するPDBエントリー: 4KB7 4KBI 4KE5 4KHM 4KHR
• 分子名称: HCV Polymerase, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid (3 entities in total)
• 機能のキーワード: hcv polymerase, hcv ns5b, site iv inhibitor, boron, rna dependent rna polymerase, transferase-transferase inhibitor complex, replication-replication inhibitor complex, replication/replication inhibitor
• 由来する生物種: Hepatitis C virus (HCV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 130862.93

構造登録者

Williams, S.P.,Kahler, K.M.,Shotwell, J.B. (登録日: 2013-04-22, 公開日: 2013-05-08, 最終更新日: 2024-03-13)

• 主引用文献: Maynard, A.,Crosby, R.M.,Ellis, B.,Hamatake, R.,Hong, Z.,Johns, B.A.,Kahler, K.M.,Koble, C.,Leivers, A.,Leivers, M.R.,Mathis, A.,Peat, A.J.,Pouliot, J.J.,Roberts, C.D.,Samano, V.,Schmidt, R.M.,Smith, G.K.,Spaltenstein, A.,Stewart, E.L.,Thommes, P.,Turner, E.M.,Voitenleitner, C.,Walker, J.T.,Waitt, G.,Weatherhead, J.,Weaver, K.,Williams, S.,Wright, L.,Xiong, Z.Z.,Haigh, D.,Shotwell, J.B.; Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase.; J.Med.Chem., 57:1902-1913, 2014; PubMed: 23672667; DOI: 10.1021/jm400317w

実験手法

X-RAY DIFFRACTION (2.3 Å)