4JLR

Crystal structure of a designed Respiratory Syncytial Virus Immunogen in complex with Motavizumab

Summary for 4JLR

• Entry DOI: 10.2210/pdb4jlr/pdb
• Descriptor: Motavizumab Fab heavy chain, Motavizumab Fab light chain, RSV_1Isea designed scaffold, ... (5 entities in total)
• Functional Keywords: antibody, designed immunogen, specific binding, rsv f protein, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 123777.45

Authors

Rupert, P.B.,Correia, B.,Schief, W.,Strong, R.K. (deposition date: 2013-03-12, release date: 2014-02-05, Last modification date: 2014-12-17)

• Primary citation: Correia, B.E.,Bates, J.T.,Loomis, R.J.,Baneyx, G.,Carrico, C.,Jardine, J.G.,Rupert, P.,Correnti, C.,Kalyuzhniy, O.,Vittal, V.,Connell, M.J.,Stevens, E.,Schroeter, A.,Chen, M.,Macpherson, S.,Serra, A.M.,Adachi, Y.,Holmes, M.A.,Li, Y.,Klevit, R.E.,Graham, B.S.,Wyatt, R.T.,Baker, D.,Strong, R.K.,Crowe, J.E.,Johnson, P.R.,Schief, W.R.; Proof of principle for epitope-focused vaccine design.; Nature, 507:201-206, 2014; PubMed: 24499818; DOI: 10.1038/nature12966

Experimental method

X-RAY DIFFRACTION (2.71 Å)