4J6R

Crystal structure of broadly and potently neutralizing antibody VRC23 in complex with HIV-1 gp120

Summary for 4J6R

• Entry DOI: 10.2210/pdb4j6r/pdb
• Related: 3SE8 3SE9 3U7Y 4JB9
• Descriptor: Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY VRC23, LIGHT CHAIN OF ANTIBODY VRC23, ... (10 entities in total)
• Functional Keywords: hiv, gp120, cd4-binding site, vrc23, neutralization, vaccine, antibody, envelope protein, immune system, viral protein-immune system complex, viral protein/immune system
• Biological source: HUMAN IMMUNODEFICIENCY VIRUS 1; More
• Total number of polymer chains: 3
• Total formula weight: 90604.45

Authors

Zhou, T.,Moquin, S.,Kwong, P.D. (deposition date: 2013-02-11, release date: 2013-05-08, Last modification date: 2023-09-20)

• Primary citation: Georgiev, I.S.,Doria-Rose, N.A.,Zhou, T.,Kwon, Y.D.,Staupe, R.P.,Moquin, S.,Chuang, G.Y.,Louder, M.K.,Schmidt, S.D.,Altae-Tran, H.R.,Bailer, R.T.,McKee, K.,Nason, M.,O'Dell, S.,Ofek, G.,Pancera, M.,Srivatsan, S.,Shapiro, L.,Connors, M.,Migueles, S.A.,Morris, L.,Nishimura, Y.,Martin, M.A.,Mascola, J.R.,Kwong, P.D.; Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.; Science, 340:751-756, 2013; PubMed: 23661761; DOI: 10.1126/science.1233989

Experimental method

X-RAY DIFFRACTION (1.64 Å)