4J1V

Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor pathway, in HCV replication

Summary for 4J1V

• Entry DOI: 10.2210/pdb4j1v/pdb
• Descriptor: MOB kinase activator 1A, NS5A domain II peptide, ZINC ION, ... (4 entities in total)
• Functional Keywords: hcv ns5a binding protein, ns5a, peptide binding protein-viral protein complex, peptide binding protein/viral protein
• Biological source: Homo sapiens (human); More
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q99IB8
• Total number of polymer chains: 6
• Total formula weight: 52516.55

Authors

Chung, H.-Y.,Gu, M.,Rice, C.M. (deposition date: 2013-02-02, release date: 2014-08-06, Last modification date: 2024-02-28)

• Primary citation: Chung, H.Y.,Gu, M.,Buehler, E.,MacDonald, M.R.,Rice, C.M.; Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction.; J.Virol., 88:11022-11033, 2014; PubMed: 25031347; DOI: 10.1128/JVI.01582-14

Experimental method

X-RAY DIFFRACTION (1.95 Å)