4J19

Structure of a novel telomere repeat binding protein bound to DNA

Summary for 4J19

• Entry DOI: 10.2210/pdb4j19/pdb
• Descriptor: Homeobox-containing protein 1, DNA (5'-D(*CP*TP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*A)-3'), ... (5 entities in total)
• Functional Keywords: telomere repeat binding, telomeric dna, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus . Isoform 5: Nucleus : Q6NT76
• Total number of polymer chains: 4
• Total formula weight: 37865.87

Authors

Kappei, D.,Butter, F.,Benda, C.,Scheibe, M.,Draskovic, I.,Stevense, M.,Lopes Novo, C.,Basquin, C.,Krastev, D.B.,Kittler, R.,Jessberger, R.,Londono-Vallejo, A.J.,Mann, M.,Buchholz, F. (deposition date: 2013-02-01, release date: 2013-05-29, Last modification date: 2023-09-20)

• Primary citation: Kappei, D.,Butter, F.,Benda, C.,Scheibe, M.,Draskovic, I.,Stevense, M.,Novo, C.L.,Basquin, C.,Araki, M.,Araki, K.,Krastev, D.B.,Kittler, R.,Jessberger, R.,Londono-Vallejo, J.A.,Mann, M.,Buchholz, F.; HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.; Embo J., 32:1681-1701, 2013; PubMed: 23685356; DOI: 10.1038/emboj.2013.105

Experimental method

X-RAY DIFFRACTION (2.9 Å)