4I33

Crystal structure of HCV NS3/4A R155K protease complexed with compound 4

Summary for 4I33

• Entry DOI: 10.2210/pdb4i33/pdb
• Descriptor: Genome polyprotein, HCV non-structural protein 4A, SODIUM ION, ... (5 entities in total)
• Functional Keywords: hepatitis c virus, ns3, ns4a, protein-inhibitor complex compound 4, serine protease, r155k, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Hepatitis C virus (HCV); More
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26662 P26662
• Total number of polymer chains: 4
• Total formula weight: 44846.07

Authors

Lemke, C.T. (deposition date: 2012-11-23, release date: 2013-01-02, Last modification date: 2013-03-13)

• Primary citation: O'Meara, J.A.,Lemke, C.T.,Godbout, C.,Kukolj, G.,Lagace, L.,Moreau, B.,Thibeault, D.,White, P.W.,Llinas-Brunet, M.; Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance.; J.Biol.Chem., 288:5673-5681, 2013; PubMed: 23271737; DOI: 10.1074/jbc.M112.439455

Experimental method

X-RAY DIFFRACTION (1.9001 Å)